Learning smoothing models of copy number profiles using breakpoint annotations.

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Authors
  • HOCKING Toby
  • SCHLEIERMACHER Gudrun
  • JANOUEIX LEROSEY Isabelle
  • BOEVA Valentina
  • CAPPO Julie
  • DELATTRE Olivier
  • BACH Francis
  • VERT Jean philippe
  • HOCKING Toby dylan
Publication date
2013
Publication type
Journal Article
Summary Many models have been proposed to detect copy number alterations in chromosomal copy number profiles, but it is usually not obvious to decide which is most effective for a given data set. Furthermore, most methods have a smoothing parameter that determines the number of breakpoints and must be chosen using various heuristics.
Publisher
Springer Science and Business Media LLC
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